Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT76OLR)

• DTT Name: Vitamin K-dependent gamma-carboxylase (GGCX)
• Synonyms: Vitamin K gamma glutamyl carboxylase; Gamma-glutamyl carboxylase; GGCX
• Gene Name: GGCX
• DTT Type: Successful target; [1]
• BioChemical Class: Carbon-carbon lyase
• UniProt ID: VKGC_HUMAN
• TTD ID: T88182
• EC Number: EC 4.1.1.90
• Sequence:
  MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTD
  PASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYT
  IMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYW
  SVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSP
  FKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFS
  YVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRH
  QLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRT
  GELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQR
  IFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHL
  ENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYM
  YVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFL
  RRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEV
  TYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF
• Function: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
• KEGG Pathway: Ubiquinone and other terpenoid-quinone biosynthesis (hsa00130)
• Reactome Pathway: Gamma-carboxylation of protein precursors (R-HSA-159740)
• BioCyc Pathway: MetaCyc:HS03897-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[1]

References

• [1] Quinone oxidoreductases and vitamin K metabolism. Vitam Horm. 2008;78:85-101.