| DTT Name |
HUMAN casein kinase II alpha prime (CSNK2A2)
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| Synonyms |
Casein kinase II subunit alpha'; CK2A2; CK II alpha' |
| Gene Name |
CSNK2A2
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| BioChemical Class |
Kinase
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 2.7.11.1
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| Sequence |
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
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| Function |
Human protein casein kinase 2 alpha 2 interacts with SARS-CoV-2 N protein with high significance, which indicates CSNK2A2 as a potential therapeutic target. |
| KEGG Pathway |
- Ribosome biogenesis in eukaryotes (hsa03008 )
- NF-kappa B signaling pathway (hsa04064 )
- Mitophagy - animal (hsa04137 )
- Wnt signaling pathway (hsa04310 )
- Adherens junction (hsa04520 )
- Alzheimer disease (hsa05010 )
- Prion disease (hsa05020 )
- Pathways of neurodegeneration - multiple diseases (hsa05022 )
- Measles (hsa05162 )
- PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
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| Reactome Pathway |
- WNT mediated activation of DVL (R-HSA-201688 )
- Condensation of Prometaphase Chromosomes (R-HSA-2514853 )
- Signal transduction by L1 (R-HSA-445144 )
- Regulation of TP53 Activity through Phosphorylation (R-HSA-6804756 )
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (R-HSA-6814122 )
- Receptor Mediated Mitophagy (R-HSA-8934903 )
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (R-HSA-8939243 )
- Regulation of PTEN stability and activity (R-HSA-8948751 )
- KEAP1-NFE2L2 pathway (R-HSA-9755511 )
- Synthesis of PC (R-HSA-1483191 )
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