Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7LTUJ)

DTT Name Fas messenger RNA (FAS mRNA)
Synonyms
Tumor necrosis factor receptor superfamily member 6 (mRNA); TNFRSF6 (mRNA); FASLG receptor (mRNA); FAS1 (mRNA); CD95 (mRNA); Apoptosis-mediating surface antigen FAS (mRNA); Apo-1 antigen (mRNA); APT1 (mRNA)
Gene Name FAS
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
TNR6_HUMAN
TTD ID
T04945
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCH
KPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCT
RTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLL
LLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVM
TLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKK
ANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
Function
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Receptor for TNFSF6/FASLG.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
Cytokine-cytokine receptor interaction (hsa04060 )
p53 signaling pathway (hsa04115 )
Apoptosis (hsa04210 )
Natural killer cell mediated cytotoxicity (hsa04650 )
TNF signaling pathway (hsa04668 )
Non-alcoholic fatty liver disease (NAFLD) (hsa04932 )
Type I diabetes mellitus (hsa04940 )
Alzheimer's disease (hsa05010 )
Chagas disease (American trypanosomiasis) (hsa05142 )
African trypanosomiasis (hsa05143 )
Hepatitis B (hsa05161 )
Measles (hsa05162 )
Influenza A (hsa05164 )
Herpes simplex infection (hsa05168 )
Pathways in cancer (hsa05200 )
Proteoglycans in cancer (hsa05205 )
Autoimmune thyroid disease (hsa05320 )
Allograft rejection (hsa05330 )
Graft-versus-host disease (hsa05332 )
Reactome Pathway
FasL/ CD95L signaling (R-HSA-75157 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 17020 DMXMHJV Discovery agent N.A. Investigative [1]
------------------------------------------------------------------------------------

References

1 US patent application no. 6,204,055, Antisense inhibition of Fas mediated signaling.