General Information of Drug Therapeutic Target (DTT) (ID: TT7M3PI)

DTT Name Ribosomal protein S6 kinase (S6K)
Synonyms Ribosomal s6 kinase
Gene Name S6K
DTT Type
Clinical trial target
[1]
BioChemical Class
Kinase
UniProt ID
NOUNIPROTAC
TTD ID
T45597

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY-2584702 DML8M3B Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
LY2780301 DM93AJW Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
LYS-6KAKT1 DMLXGAI Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
XL418 DME0F5W Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
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1 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27410995-Compound-Figure3k DMJ0QLB N. A. N. A. Patented [5]
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References

1 DOI: 10.1016/S1359-6349(10)71767-5
2 A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.Eur J Cancer.2014 Mar;50(5):876-84.
3 A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Invest New Drugs. 2015 Jun;33(3):710-9.
4 Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer
5 Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78.