Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7OGZP)

• DTT Name: Casein kinase 1 (CK1)
• Gene Name: CK1
• DTT Type: Preclinical target; [1]
• UniProt ID: KC1A_HUMAN ; KC1D_HUMAN ; KC1E_HUMAN ; KC1G1_HUMAN ; KC1G2_HUMAN ; KC1G3_HUMAN
• TTD ID: T72915
• KEGG Pathway:
  Wnt signaling pathway (hsa04310)
  Hedgehog signaling pathway (hsa04340)
  Alzheimer disease (hsa05010)
  Pathways of neurodegeneration - multiple diseases (hsa05022)
  Human papillomavirus infection (hsa05165)
  Breast cancer (hsa05224)
  Hepatocellular carcinoma (hsa05225)
  Gastric cancer (hsa05226)
• Reactome Pathway:
  Beta-catenin phosphorylation cascade (R-HSA-196299)
  Disassembly of the destruction complex and recruitment of AXIN to the membrane (R-HSA-4641262)
  Signaling by GSK3beta mutants (R-HSA-5339716)
  CTNNB1 S33 mutants aren't phosphorylated (R-HSA-5358747)
  CTNNB1 S37 mutants aren't phosphorylated (R-HSA-5358749)
  CTNNB1 S45 mutants aren't phosphorylated (R-HSA-5358751)
  CTNNB1 T41 mutants aren't phosphorylated (R-HSA-5358752)
  APC truncation mutants have impaired AXIN binding (R-HSA-5467337)
  AXIN missense mutants destabilize the destruction complex (R-HSA-5467340)
  Truncations of AMER1 destabilize the destruction complex (R-HSA-5467348)
  Degradation of GLI2 by the proteasome (R-HSA-5610783)
  GLI3 is processed to GLI3R by the proteasome (R-HSA-5610785)
  Activation of SMO (R-HSA-5635838)
  Maturation of nucleoprotein (R-HSA-9694631)
  Degradation of beta-catenin by the destruction complex (R-HSA-195253)

Molecular Interaction Atlas (MIA) of This DTT

2 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CKI-7	DMV0RFU	Mood disorder	6A60-6E23	Preclinical	[1]
LH846	DMJXZIS	Mood disorder	6A60-6E23	Preclinical	[2]

References

• [1] Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. PLoS One. 2011 May 9;6(5):e19589.
• [2] A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11.