Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7QSMG)

DTT Name	Testis-enhanced gene transcript protein (TMBIM6)
Synonyms	Testis enhanced gene transcript; TMBIM6; BI-1
Gene Name	TMBIM6
DTT Type	Literature-reported target	[1]
UniProt ID	BI1_HUMAN
TTD ID	T29594
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLS ALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMG TAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVV MCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK
Function	Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel.
KEGG Pathway	Pathogenic Escherichia coli infection (hsa05130 )

References

1	Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carc... Am J Pathol. 2003 Aug;163(2):543-52.