Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7ZMY4)

DTT Name Lysophosphatidic acid receptor 4 (LPAR4)
Synonyms Purinergic receptor 9; P2Y9; P2Y5-like receptor; P2Y purinoceptor 9; P2RY9; LPA4; LPA-4; LPA receptor 4; GPR23; G-protein coupled receptor 23
Gene Name LPAR4
DTT Type
Literature-reported target
 [1]
UniProt ID
LPAR4_HUMAN
TTD ID
T58130
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVS
LFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLT
NIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTN
VNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQI
GTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCFLERFAKIMYPITLCLA
TLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTTKPSLPAIQEEVSDQTTNN
GGELMLESTF
Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
KEGG Pathway
Rap1 signaling pathway (hsa04015 )
Phospholipase D signaling pathway (hsa04072 )
Neuroactive ligand-receptor interaction (hsa04080 )
PI3K-Akt signaling pathway (hsa04151 )
Regulation of actin cytoskeleton (hsa04810 )
Pathogenic Escherichia coli infection (hsa05130 )
Pathways in cancer (hsa05200 )
Reactome Pathway
P2Y receptors (R-HSA-417957 )
G alpha (q) signalling events (R-HSA-416476 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
LPA DMI5XR1 Discovery agent N.A. Investigative [1]
[1-bromo-(3S)-hydrox-4-(palmitoyloxy)butyl]phosphate DMS1YN3 Discovery agent N.A. Investigative [2]
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References

1 Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003 Jul 11;278(28):25600-6.
2 LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31.