General Information of Drug Therapeutic Target (DTT) (ID: TT80QAL)

DTT Name Transcription factor 7-like 2 (TCF7L2)
Synonyms TCF4; TCF-4; T-cell-specific transcription factor 4; T-cell transcription factor-4; T-cell factor 4; HTCF-4; HMG box transcription factor 4
Gene Name TCF7L2
DTT Type
Literature-reported target
[1]
UniProt ID
TF7L2_HUMAN
TTD ID
T54646
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP
AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS
PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP
HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY
MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR
DNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPC
RRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKP
DPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSH
SSLAGTQPQPLSLVTKSLE
Function
Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner.
KEGG Pathway
Wnt signaling pathway (hsa04310 )
Hippo signaling pathway (hsa04390 )
Adherens junction (hsa04520 )
Melanogenesis (hsa04916 )
Cushing syndrome (hsa04934 )
Alcoholic liver disease (hsa04936 )
Salmonella infection (hsa05132 )
Human papillomavirus infection (hsa05165 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Pathways in cancer (hsa05200 )
Colorectal cancer (hsa05210 )
Endometrial cancer (hsa05213 )
Prostate cancer (hsa05215 )
Thyroid cancer (hsa05216 )
Basal cell carcinoma (hsa05217 )
Acute myeloid leukemia (hsa05221 )
Breast cancer (hsa05224 )
Hepatocellular carcinoma (hsa05225 )
Gastric cancer (hsa05226 )
Arrhythmogenic right ventricular cardiomyopathy (hsa05412 )
Reactome Pathway
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402 )
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (R-HSA-381771 )
Ca2+ pathway (R-HSA-4086398 )
Binding of TCF/LEF (R-HSA-4411364 )
Repression of WNT target genes (R-HSA-4641265 )
Signaling by TCF7L2 mutants (R-HSA-5339700 )
Transcriptional Regulation by VENTX (R-HSA-8853884 )
RUNX3 regulates WNT signaling (R-HSA-8951430 )
Formation of the beta-catenin (R-HSA-201722 )

References

1 Aberrant expression and function of TCF4 in the proliferation of hepatocellular carcinoma cell line BEL-7402. Cell Res. 2004 Feb;14(1):74-80.