Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT89Z17)

DTT Name B7 translation initiation codon region messenger RNA (CD80 mRNA)
Synonyms T-lymphocyte activation antigen CD80 (mRNA); LAB7 (mRNA); CTLA-4 counter-receptor B7.1 (mRNA); CD28LG1 (mRNA); CD28LG (mRNA); BB1 (mRNA); B7 (mRNA); Activation B7-1 antigen (mRNA)
Gene Name CD80
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
CD80_HUMAN
TTD ID
T29148
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELA
QTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLK
YEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGE
ELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFP
DNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
Function
T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. Involved in the costimulatory signal essential for T-lymphocyte activation.
KEGG Pathway
Cell adhesion molecules (CAMs) (hsa04514 )
Toll-like receptor signaling pathway (hsa04620 )
Intestinal immune network for IgA production (hsa04672 )
Type I diabetes mellitus (hsa04940 )
Autoimmune thyroid disease (hsa05320 )
Systemic lupus erythematosus (hsa05322 )
Rheumatoid arthritis (hsa05323 )
Allograft rejection (hsa05330 )
Graft-versus-host disease (hsa05332 )
Viral myocarditis (hsa05416 )
Reactome Pathway
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530 )
CD28 co-stimulation (R-HSA-389356 )
CD28 dependent PI3K/Akt signaling (R-HSA-389357 )
CD28 dependent Vav1 pathway (R-HSA-389359 )
CTLA4 inhibitory signaling (R-HSA-389513 )
PIP3 activates AKT signaling (R-HSA-1257604 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 13805 DMLVKPD Discovery agent N.A. Investigative [1]
ISIS 13812 DMPXCZ7 Discovery agent N.A. Investigative [1]
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References

1 US patent application no. 6,319,906, Oligonucleotide compositions and methods for the modulation of the expression of B7 protein.