Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8CWJG)

DTT Name	Alpha-crystallin A chain (CRYAA)
Synonyms	HspB4; Heat shock protein beta-4; CRYA1
Gene Name	CRYAA
DTT Type	Literature-reported target	[1]
BioChemical Class	Heat shock protein
UniProt ID	CRYAA_HUMAN
TTD ID	T38610
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSG ISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRL PSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS
Function	Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Contributes to the transparency and refractive index of the lens.
KEGG Pathway	Protein processing in endoplasmic reticulum (hsa04141 )

References

1	Identification of the HSPB4/TLR2/NF-B axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO Mol Med. 2012 May;4(5):435-48.