Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8FRMO)

DTT Name Interleukin-7 (IL7)
Synonyms Interleukin7; IL-7
Gene Name IL7
DTT Type
Clinical trial target
 [1]
BioChemical Class
Cytokine: interleukin
UniProt ID
IL7_HUMAN
TTD ID
T35232
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCL
NNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQ
VKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
Function It is important for proliferation during certain stages of B-cell maturation. Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
PI3K-Akt signaling pathway (hsa04151 )
Jak-STAT signaling pathway (hsa04630 )
Hematopoietic cell lineage (hsa04640 )
Reactome Pathway
Interleukin-7 signaling (R-HSA-1266695 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ASP9801 DMCDMPW Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
GSK2618960 DMIVHDN Multiple sclerosis 8A40 Phase 1 [1]
GSK3888130? DMKD6IV Multiple sclerosis 8A40 Phase 1 [3]
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References

1 ClinicalTrials.gov (NCT02293161) Single Ascending Doses Study of Anti- Interleukin-7 Receptor alpha Monoclonal Antibody (GSK2618960) in Healthy Volunteers. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Astellas Pharma.
3 Clinical pipeline report, company report or official report of GlaxoSmithKline