Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8K17W)

DTT Name Histone deacetylase 11 (HDAC11)
Synonyms HD11
Gene Name HDAC11
DTT Type
Patented-recorded target
 [1]
BioChemical Class
Carbon-nitrogen hydrolase
UniProt ID
HDA11_HUMAN
TTD ID
T97903
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 3.5.1.98
Sequence
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
Function
Gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
KEGG Pathway
Alcoholism (hsa05034 )
Viral carcinogenesis (hsa05203 )
Reactome Pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants (R-HSA-2644606 )
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862 )
Notch-HLH transcription pathway (R-HSA-350054 )
NOTCH1 Intracellular Domain Regulates Transcription (R-HSA-2122947 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
7 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID29671355-Compound-21 DMPJN0M N. A. N. A. Patented [1]
PMID29671355-Compound-23 DMUBOEX N. A. N. A. Patented [1]
PMID29671355-Compound-25 DMPV0KZ N. A. N. A. Patented [1]
PMID29671355-Compound-36 DMQJ3TC N. A. N. A. Patented [1]
PMID29671355-Compound-43 DMVPMWJ N. A. N. A. Patented [1]
PMID29671355-Compound-44 DM80A3V N. A. N. A. Patented [1]
PMID29671355-Compound-62 DMWRS34 N. A. N. A. Patented [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 7 Patented Agent(s)

References

1 HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17.