Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8KLPT)

• DTT Name: C-C chemokine receptor (CCR)
• Synonyms: Chemokine (C-C motif) receptor
• Gene Name: CCR
• DTT Type: Literature-reported target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T71054
• Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
• KEGG Pathway:
  Cytokine-cytokine receptor interaction (hsa04060)
  Chemokine signaling pathway (hsa04062)
• Reactome Pathway:
  Binding and entry of HIV virion (R-HSA-173107)
  Chemokine receptors bind chemokines (R-HSA-380108)
  G alpha (i) signalling events (R-HSA-418594)
  Beta defensins (R-HSA-1461957)

Molecular Interaction Atlas (MIA) of This DTT

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CP-481,715	DMZT7C1	Discovery agent	N.A.	Investigative	[2]
PMID12614873C2b-1	DMXFY4P	Discovery agent	N.A.	Investigative	[3]
UCB35625	DMQB8C3	Discovery agent	N.A.	Investigative	[4]
viral macrophage inflammatory protein-II	DMAXOPS	Discovery agent	N.A.	Investigative	[5]
VT-224	DMB7I0A	Inflammation	1A00-CA43.1	Investigative	[1]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 67).
• [2] CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. J Biol Chem. 2003 Oct 17;278(42):40473-80.
• [3] Structure-activity relationships of xanthene carboxamides, novel CCR1 receptor antagonists. Bioorg Med Chem. 2003 Mar 20;11(6):875-84.
• [4] A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 2000 Aug 25;275(34):25985-92.
• [5] A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9.