Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8ME6I)

DTT Name	Osteopontin (SPP1)
Synonyms	Uropontin; Urinary stone protein; Secreted phosphoprotein 1; SPP-1; PSEC0156; OPN; Nephropontin; Bone sialoprotein 1; BNSP
Gene Name	SPP1
DTT Type	Literature-reported target	[1]
UniProt ID	OSTP_HUMAN
TTD ID	T00032
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNA VSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQS DESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQ YPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSH KQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKF RISHELDSASSEVN
Function	Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Binds tightly to hydroxyapatite.
KEGG Pathway	PI3K-Akt signaling pathway (hsa04151 ) Apelin signaling pathway (hsa04371 ) Focal adhesion (hsa04510 ) ECM-receptor interaction (hsa04512 ) Toll-like receptor signaling pathway (hsa04620 ) GnRH secretion (hsa04929 ) Human papillomavirus infection (hsa05165 )
Reactome Pathway	Signaling by PDGF (R-HSA-186797 ) Integrin cell surface interactions (R-HSA-216083 ) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 ) RUNX3 Regulates Immune Response and Cell Migration (R-HSA-8949275 ) Post-translational protein phosphorylation (R-HSA-8957275 ) Degradation of the extracellular matrix (R-HSA-1474228 )

References

1	The use of biomarkers for assessing HAART-associated renal toxicity in HIV-infected patients. Curr HIV Res. 2012 Sep;10(6):521-31.