Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8OY02)

DTT Name ARA70 messenger RNA (NCOA4 mRNA)
Synonyms
Ret-activating protein ELE1 (mRNA); RFG (mRNA); Nuclear receptor coactivator 4 (mRNA); NCoA-4 (mRNA); ELE1 (mRNA); Androgen receptor-associated protein of 70 kDa (mRNA); Androgen receptor coactivator 70 kDa protein (mRNA); ARA70 (mRNA); ARA70 (dARA70N) (mRNA); 70 kDa androgen receptor coactivator (mRNA); 70 kDa AR-activator (mRNA)
Gene Name NCOA4
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
NCOA4_HUMAN
TTD ID
T39134
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHL
ECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSV
CLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTS
SRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMD
LSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEI
ENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDE
NCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPS
RIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWV
LPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLK
VDKEKWLYRTPLQM
Function Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Enhances the androgen receptor transcriptional activity in prostate cancer cells.
KEGG Pathway
Pathways in cancer (hsa05200 )
Thyroid cancer (hsa05216 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
8 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 114371 DMBO3YT Discovery agent N.A. Investigative [1]
ISIS 114372 DMNTRKI Discovery agent N.A. Investigative [1]
ISIS 114388 DMIZH16 Discovery agent N.A. Investigative [1]
ISIS 114390 DM1H428 Discovery agent N.A. Investigative [1]
ISIS 114397 DMCBXQK Discovery agent N.A. Investigative [1]
ISIS 114399 DMZVE0S Discovery agent N.A. Investigative [1]
ISIS 114404 DMIOWBH Discovery agent N.A. Investigative [1]
ISIS 114442 DMCVP5G Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 8 Investigative Drug(s)

References

1 US patent application no. 6,255,110, Antisense modulation of ARA70 expression.