Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8RDXP)

DTT Name Troponin C (TN-C)
Synonyms Troponin C, slow skeletal and cardiac muscles; TNNC
Gene Name TNNC1
DTT Type
Successful target
 [1]
UniProt ID
TNNC1_HUMAN
TTD ID
T12966
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEM
IDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIM
LQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
Function
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
KEGG Pathway
Calcium signaling pathway (hsa04020 )
Cardiac muscle contraction (hsa04260 )
Adrenergic signaling in cardiomyocytes (hsa04261 )
Hypertrophic cardiomyopathy (HCM) (hsa05410 )
Dilated cardiomyopathy (hsa05414 )
Reactome Pathway
Striated Muscle Contraction (R-HSA-390522 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydroxyaluminium DM8YXKW Skin inflammation EF20.Y Approved [2]
Levosimendan DMKBOS2 Congestive heart failure BD10 Approved [1]
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References

1 Timing of levosimendan in cardiac surgery. Anadolu Kardiyol Derg. 2009 Jun;9(3):223-30.
2 A retrospective analysis of changes in inflammatory markers in patients treated with bacterial viruses. Clin Exp Med. 2009 Dec;9(4):303-12.