Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8WXAV)

• DTT Name: Transferrin messenger RNA (TF mRNA)
• Synonyms: Transferrin (mRNA); Siderophilin (mRNA); Serotransferrin (mRNA); PRO1400 (mRNA); Beta-1 metal-binding globulin (mRNA)
• Gene Name: TF
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: TRFE_HUMAN
• TTD ID: T73245
• Sequence:
  MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVK
  KASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVV
  KKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPC
  ADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRD
  QYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKE
  FQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKP
  VKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGK
  CGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWN
  IPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAF
  RCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR
  APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKL
  HDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP
• Function: It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
• KEGG Pathway:
  HIF-1 signaling pathway (hsa04066)
  Mineral absorption (hsa04978)
• Reactome Pathway:
  Iron uptake and transport (R-HSA-917937)
  Transferrin endocytosis and recycling (R-HSA-917977)
  Platelet degranulation (R-HSA-114608)

References

• [1] Identifying Cancer Subtypes from miRNA-TF-mRNA Regulatory Networks and Expression Data. PLoS One. 2016 Apr 1;11(4):e0152792.