Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT90CMU)

DTT Name	Cholecystokinin (CCK)
Synonyms	Procholecystokinin; CCK
Gene Name	CCK
DTT Type	Literature-reported target	[1]
BioChemical Class	Gastrin cholecystokinin
UniProt ID	CCKN_HUMAN
TTD ID	T24089
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGA LLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS
Function	This peptide hormone induces gall bladder contraction and therelease of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
KEGG Pathway	Neuroactive ligand-receptor interaction (hsa04080 ) Insulin secretion (hsa04911 ) Pancreatic secretion (hsa04972 )
Reactome Pathway	G alpha (q) signalling events (R-HSA-416476 ) Peptide ligand-binding receptors (R-HSA-375276 )

References

1	Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin re... Digestion. 1999;60 Suppl 1:69-74.