Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT915ZD)

• DTT Name: Candida Mannose-6-phosphate isomerase (Candi PMI1)
• Synonyms: Phosphomannose isomerase; Phosphohexomutase; PMI1; PMI
• Gene Name: Candi PMI1
• DTT Type: Successful target; [1]
• Related Disease:
  Acne vulgaris [ICD-11: ED80]
  Dermatitis herpetiformis [ICD-11: EB44]
• BioChemical Class: Intramolecular oxidoreductases
• UniProt ID: MPI_CANAL
• TTD ID: T34287
• Sequence:
  MSSEKLFRIQCGYQNYDWGKIGSSSAVAQFVHNSDPSITIDETKPYAELWMGTHPSVPSK
  AIDLNNQTLRDLVTAKPQEYLGESIITKFGSSKELPFLFKVLSIEKVLSIQAHPDKKLGA
  QLHAADPKNYPDDNHKPEMAIAVTDFEGFCGFKPLDQLAKTLATVPELNEIIGQELVDEF
  ISGIKLPAEVGSQDDVNNRKLLQKVFGKLMNTDDDVIKQQTAKLLERTDREPQVFKDIDS
  RLPELIQRLNKQFPNDIGLFCGCLLLNHVGLNKGEAMFLQAKDPHAYISGDIIECMAASD
  NVVRAGFTPKFKDVKNLVEMLTYSYESVEKQKMPLQEFPRSKGDAVKSVLYDPPIAEFSV
  LQTIFDKSKGGKQVIEGLNGPSIVIATNGKGTIQITGDDSTKQKIDTGYVFFVAPGSSIE
  LTADSANQDQDFTTYRAFVEA
• Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
• KEGG Pathway:
  Fructose and mannose metabolism (cal00051)
  Amino sugar and nucleotide sugar metabolism (cal00520)
  Metabolic pathways (cal01100)
  Biosynthesis of secondary metabolites (cal01110)
  Biosynthesis of cofactors (cal01240)
  Biosynthesis of nucleotide sugars (cal01250)

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfacetamide	DMZ6VEY	Acne vulgaris	ED80	Approved	[1]
Sulfoxone	DMAYX6P	Dermatitis herpetiformis	EB44	Approved	[1]

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[2]
GNF-PF-2272	DMONK0F	Discovery agent	N.A.	Investigative	[3]
GNF-PF-5134	DM7850H	Discovery agent	N.A.	Investigative	[3]
NSC-66209	DMQ0S4B	Discovery agent	N.A.	Investigative	[3]

References

• [1] Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs. 2000;7(1):49-54.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.