Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT92EIB)

DTT Name ADORA1 messenger RNA (ADORA1 mRNA)
Synonyms Adenosine receptor A1 (mRNA); A(1) adenosine receptor (mRNA)
Gene Name ADORA1
DTT Type
Clinical trial target
 [1]
BioChemical Class
mRNA target
UniProt ID
AA1R_HUMAN
TTD ID
T88714
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
Function The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Receptor for adenosine.
KEGG Pathway
cGMP-PKG signaling pathway (hsa04022 )
cAMP signaling pathway (hsa04024 )
Sphingolipid signaling pathway (hsa04071 )
Neuroactive ligand-receptor interaction (hsa04080 )
Regulation of lipolysis in adipocytes (hsa04923 )
Renin secretion (hsa04924 )
Morphine addiction (hsa05032 )
Reactome Pathway
G alpha (i) signalling events (R-HSA-418594 )
Adenosine P1 receptors (R-HSA-417973 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Neladenoson bialanate DMSVWI7 Chronic heart failure BD1Z Phase 2 [1]
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1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
EPI-2010 DMJ52FZ Asthma CA23 Discontinued in Phase 2 [2]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Asthma CA23 Nasal and bronchial airway 1.74E-01 -0.13 -0.36
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 RASONs: a novel antisense oligonucleotide therapeutic approach for asthma. Expert Opin Biol Ther. 2001 Nov;1(6):979-83.