Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9AZWY)

DTT Name HSPB1 messenger RNA (HSPB1 mRNA)
Synonyms
Stress-responsive protein 27 (mRNA); SRP27 (mRNA); HspB1 (mRNA); Heat shock protein beta-1 (mRNA); Heat shock 27 kDa protein (mRNA); HSP28 (mRNA); HSP 27 (mRNA); Estrogen-regulated 24 kDa protein (mRNA); 28 kDa heat shock protein (mRNA)
Gene Name HSPB1
DTT Type
Discontinued target
 [1]
BioChemical Class
mRNA target
UniProt ID
HSPB1_HUMAN
TTD ID
T11253
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPP
AAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEI
TGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEIT
IPVTFESRAQLGGPEAAKSDETAAK
Function
Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
VEGF signaling pathway (hsa04370 )
Amoebiasis (hsa05146 )
Epstein-Barr virus infection (hsa05169 )
Reactome Pathway
MAPK6/MAPK4 signaling (R-HSA-5687128 )
VEGFA-VEGFR2 Pathway (R-HSA-4420097 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
SB-242235 DMKSFL0 Arthritis FA20 Discontinued in Phase 1 [1]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Prostate cancer 2C82 Prostate 6.15E-13 -0.64 -1.66
Ovarian cancer 2C82 Ovarian tissue 3.12E-01 0.46 0.54
Lung cancer 2C82 Lung tissue 4.18E-08 0.22 0.54
Breast cancer 2C82 Breast tissue 3.31E-42 0.96 1.29
Rheumatoid arthritis FA20 Synovial tissue 1.49E-03 1.68 2.24
Bladder cancer 2C82 Bladder tissue 3.30E-05 -0.48 -2.45
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⏷ Show the Full List of DTT Expression Under 6 Diseases

References

1 Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7.