Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9GR53)

DTT Name Smad1 messenger RNA (SMAD1 mRNA)
Synonyms
Transforming growth factor-beta-signaling protein 1 (mRNA); Smad1 (mRNA); SMAD family member 1 (mRNA); SMAD 1 (mRNA); Mothers against decapentaplegic homolog 1 (mRNA); Mothers against DPP homolog 1 (mRNA); Mad-related protein 1 (mRNA); MADR1 (mRNA); MADH1 (mRNA); MAD homolog 1 (mRNA); JV4-1 (mRNA); BSP1 (mRNA); BSP-1 (mRNA)
Gene Name SMAD1
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
SMAD1_HUMAN
TTD ID
T78475
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Function
SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase.
KEGG Pathway
TGF-beta signaling pathway (hsa04350 )
Hippo signaling pathway (hsa04390 )
Signaling pathways regulating pluripotency of stem cells (hsa04550 )
Transcriptional misregulation in cancer (hsa05202 )
Reactome Pathway
Ub-specific processing proteases (R-HSA-5689880 )
RUNX2 regulates bone development (R-HSA-8941326 )
Signaling by BMP (R-HSA-201451 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 28405 DMGMKH3 Discovery agent N.A. Investigative [1]
ISIS 28407 DMXKRWN Discovery agent N.A. Investigative [1]
ISIS 28425 DMR24BS Discovery agent N.A. Investigative [1]
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References

1 US patent application no. 6,159,697, Antisense modulation of Smad7 expression.