Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9NVXQ)

• DTT Name: Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC)
• Synonyms: PURH; OK/SW-cl.86; Bifunctional purine biosynthesis protein PURH
• Gene Name: ATIC
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Methyltransferase
• UniProt ID: PUR9_HUMAN
• TTD ID: T04741
• Sequence:
  MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
  LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA
  VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT
  HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL
  CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS
  AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG
  NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV
  ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT
  GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA
  FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
• Function: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
• KEGG Pathway:
  Purine metabolism (hsa00230)
  One carbon pool by folate (hsa00670)
  Metabolic pathways (hsa01100)
  Antifolate resistance (hsa01523)
• Reactome Pathway:
  Signaling by ALK fusions and activated point mutants (R-HSA-9725370)
  Purine ribonucleoside monophosphate biosynthesis (R-HSA-73817)
• BioCyc Pathway: MetaCyc:HS06490-MON

Molecular Interaction Atlas (MIA) of This DTT

12 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FAICAR	DMJFKSU	Discovery agent	N.A.	Investigative	[2]
NSC-126445	DMHGIB1	Discovery agent	N.A.	Investigative	[1]
NSC-26699	DM4RPBJ	Discovery agent	N.A.	Investigative	[1]
NSC-292213	DMNUSKT	Discovery agent	N.A.	Investigative	[1]
NSC-30171	DMFBZEI	Discovery agent	N.A.	Investigative	[1]
NSC-324572	DMN50OT	Discovery agent	N.A.	Investigative	[1]
NSC-37031	DMLY6WX	Discovery agent	N.A.	Investigative	[1]
NSC-37173	DMZFULS	Discovery agent	N.A.	Investigative	[1]
NSC-45592	DMQ6GBX	Discovery agent	N.A.	Investigative	[1]
NSC-47729	DMRZJL1	Discovery agent	N.A.	Investigative	[1]
NSC-58046	DMI6WA7	Discovery agent	N.A.	Investigative	[1]
NSC-88915	DM9WIHJ	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

References

• [1] Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90.
• [2] Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282(17):13033-46.