Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9O4C5)

• DTT Name: Superoxide dismutase Mn (SOD Mn)
• Synonyms: Superoxide dismutase [Mn], mitochondrial
• Gene Name: SOD2
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Superoxide dismutase/reductase
• UniProt ID: SODM_HUMAN
• TTD ID: T89147
• EC Number: EC 1.15.1.1
• Sequence:
  MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
  NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
  IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
  GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
• Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
• KEGG Pathway:
  FoxO signaling pathway (hsa04068)
  Peroxisome (hsa04146)
  Huntington's disease (hsa05016)
• Reactome Pathway:
  Detoxification of Reactive Oxygen Species (R-HSA-3299685)
  Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (R-HSA-8862803)
  Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (R-HSA-8950505)
  FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (R-HSA-9615017)
  Transcriptional activation of mitochondrial biogenesis (R-HSA-2151201)
• BioCyc Pathway: MetaCyc:HS03515-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imisopasem manganese	DME3POC	Pain	MG30-MG3Z	Phase 2	[1]

References

• [1] The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation. Free Radic Res. 2010 May;44(5):529-40.