Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAFORY)

• DTT Name: Calcitonin gene-related peptide (CALC)
• Gene Name: CALC
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T89950

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eptinezumab	DM5LJCI	Migraine	8A80	Approved	[2]

3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TEV-48125	DMMTKC6	Migraine	8A80	Phase 3	[3]
ALD-403	DM6RBYT	Migraine	8A80	Phase 2	[1]
PF-4427429	DM3427C	Migraine	8A80	Phase 1	[4]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CGRP	DMCRPKS	Asthma	CA23	Discontinued in Phase 2	[5]

References

• [1] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [3] TEV-48125 for the preventive treatment of chronic migraine: Efficacy at early time points. Neurology. 2016 Jul 5;87(1):41-8.
• [4] Teva Announces Positive Results for TEV-48125 in Phase IIb Chronic Migraine Study Meeting Primary and Secondary Endpoints
• [5] Calcitonin gene-related peptide as inflammatory mediator.Pulm Pharmacol Ther.2003;16(3):121-30.