General Information of Drug Therapeutic Target (DTT) (ID: TTAOZBW)

DTT Name Lysozyme (LYZ)
Synonyms Lysozyme C; LYZ; 1,4betaNacetylmuramidase C
Gene Name LYZ
DTT Type
Literature-reported target
[1]
BioChemical Class
Glycosylase
UniProt ID
LYSC_HUMAN
TTD ID
T10586
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.2.1.17
Sequence
MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRA
TNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRD
PQGIRAWVAWRNRCQNRDVRQYVQGCGV
Function Lysozymes have primarily a bacteriolytic function; those intissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents.
KEGG Pathway
Salivary secretion (hsa04970 )
Reactome Pathway
Antimicrobial peptides (R-HSA-6803157 )
Amyloid fiber formation (R-HSA-977225 )
Neutrophil degranulation (R-HSA-6798695 )

References

1 Protective properties of lysozyme on -amyloid pathology: implications for Alzheimer disease. Neurobiol Dis. 2015 Nov;83:122-33.