Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAPV67)

• DTT Name: Thrombomodulin (THBD)
• Synonyms: TM; THRM; Fetomodulin; CD141 antigen; CD141
• Gene Name: THBD
• DTT Type: Discontinued target; [1]
• BioChemical Class: Growth factor
• UniProt ID: TRBM_HUMAN
• TTD ID: T08583
• Sequence:
  MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM
  TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS
  RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV
  EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP
  GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP
  DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG
  ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN
  TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC
  DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR
  KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
• Function: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
• KEGG Pathway: Complement and coagulation cascades (hsa04610)
• Reactome Pathway:
  Cell surface interactions at the vascular wall (R-HSA-202733)
  Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Molecular Interaction Atlas (MIA) of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thrombomodulin	DMWNXES	Disseminated intravascular coagulation	3B20	Discontinued in Phase 3	[1]

References

• [1] Thrombomodulin. Nihon Yakurigaku Zasshi. 2000 Nov;116(5):283-9.