Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTASMD8)

• DTT Name: LIM domain kinase-2 (LIMK-2)
• Synonyms: LIMK-2; LIM domain kinase 2
• Gene Name: LIMK2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Kinase
• UniProt ID: LIMK2_HUMAN
• TTD ID: T09133
• EC Number: EC 2.7.11.1
• Sequence:
  MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
  PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
  CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
  QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
  SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
  EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
  ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
  DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
  KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
  GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
  FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
• Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
• KEGG Pathway:
  Axon guidance (hsa04360)
  Fc gamma R-mediated phagocytosis (hsa04666)
  Regulation of actin cytoskeleton (hsa04810)
  Human immunodeficiency virus 1 infection (hsa05170)
• Reactome Pathway:
  Sema4D induced cell migration and growth-cone collapse (R-HSA-416572)
  RHO GTPases Activate ROCKs (R-HSA-5627117)
  EPHB-mediated forward signaling (R-HSA-3928662)

Molecular Interaction Atlas (MIA) of This DTT

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID19831390C14	DMIECOF	Discovery agent	N.A.	Investigative	[1]
PMID19831390C22m	DM8T6VG	Discovery agent	N.A.	Investigative	[1]
PMID22902653C30	DMXDTPL	Discovery agent	N.A.	Investigative	[2]
PMID22902653C31	DMWVTAE	Discovery agent	N.A.	Investigative	[2]
PMID22902653C35	DMLVKPG	Discovery agent	N.A.	Investigative	[2]

References

• [1] Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.
• [2] Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8.