Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTATO6X)

DTT Name	Integral membrane protein GPR137 (GPR137)
Synonyms	Transmembrane 7 superfamily member 1-like 1 protein; TM7SF1L1; GPR137A; C11orf4
Gene Name	GPR137
DTT Type	Literature-reported target	[1]
UniProt ID	G137A_HUMAN
TTD ID	T96179
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MESNLSGLVPAAGLVPALPPAVTLGLTAAYTTLYALLFFSVYAQLWLVLLYGHKRLSYQT VFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCPVCLQFFTLTLMNLYFAQV VFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVLSHRRRAQPWALLLVRVLVSD SLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQAAAMGGAMVLLYASRACYNLTAL ALAPQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVFGLILFVWELLPTTLLVGFFRVHRP PQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCSWEHSRGESTRCQDQAATTTVSTPPHR RDPPPSPTEYPGPSPPHPRPLCQVCLPLLAQDPGGRGYPLLWPAPCCSCHSELVPSP
Function	It is a peptide which displays four putative transmembrane domains and is predicted to have a cytoplasmic localization. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO.

References

1	Down-regulation of GPR137 expression inhibits proliferation of colon cancer cells. RETRACTED ARTICLESee: Retraction NoticeActa Biochim Biophys Sin (Shanghai). 2014 Nov;46(11):935-41.