Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAYPWS)

DTT Name Solute carrier family 15 member 3 (SLC15A3)
Synonyms Peptide/histidine transporter 2; Peptide transporter 3; PTR3; PHT2; Osteoclast transporter; OCTP
Gene Name SLC15A3
DTT Type
Literature-reported target
 [1]
UniProt ID
S15A3_HUMAN
TTD ID
T54473
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAPRAREQPRVPGERQPLLPRGARGPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYL
NSTNFNWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPA
TAFPDGRSSFCGEMPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLT
SFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQQNISFLLGYSIPVGCVGLA
FFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQPG
ASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVA
LRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFT
SVIVAGVLEMERLHYIHHNETVSQQIGEVLYNAAPLSIWWQIPQYLLIGISEIFASIPGL
EFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPKDFGNINNCRMDL
YFFLLAGIQAVTALLFVWIAGRYERASQGPASHSRFSRDRG
Function Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).
Reactome Pathway
Proton/oligopeptide cotransporters (R-HSA-427975 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]histidine DMVUF71 Discovery agent N.A. Investigative [1]
[3H]histidine DMJ5BDQ N. A. N. A. Investigative [1]
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name Peptide/histidine transporter 2 (SLC15A3) DTP Info
Gene Name SLC15A3

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 986).