General Information of Drug Therapeutic Target (DTT) (ID: TTB6Q2O)

DTT Name Myeloid differentiation primary response protein MyD88 (MYD88)
Synonyms MyD88
Gene Name MYD88
DTT Type
Literature-reported target
[1]
UniProt ID
MYD88_HUMAN
TTD ID
T75476
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLE
IRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQ
QQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIR
QLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFA
LSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
Function
Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
NF-kappa B signaling pathway (hsa04064 )
Toll-like receptor signaling pathway (hsa04620 )
NOD-like receptor signaling pathway (hsa04621 )
Alcoholic liver disease (hsa04936 )
Pathogenic Escherichia coli infection (hsa05130 )
Shigellosis (hsa05131 )
Salmonella infection (hsa05132 )
Pertussis (hsa05133 )
Legionellosis (hsa05134 )
Yersinia infection (hsa05135 )
Leishmaniasis (hsa05140 )
Chagas disease (hsa05142 )
African trypanosomiasis (hsa05143 )
Malaria (hsa05144 )
Toxoplasmosis (hsa05145 )
Tuberculosis (hsa05152 )
Hepatitis B (hsa05161 )
Measles (hsa05162 )
Influenza A (hsa05164 )
Herpes simplex virus 1 infection (hsa05168 )
Epstein-Barr virus infection (hsa05169 )
Human immunodeficiency virus 1 infection (hsa05170 )
Coronavirus disease - COVID-19 (hsa05171 )
PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
Lipid and atherosclerosis (hsa05417 )
Reactome Pathway
PIP3 activates AKT signaling (R-HSA-1257604 )
MyD88 (R-HSA-166058 )
RIP-mediated NFkB activation via ZBP1 (R-HSA-1810476 )
p75NTR recruits signalling complexes (R-HSA-209543 )
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (R-HSA-3134963 )
MyD88 deficiency (TLR2/4) (R-HSA-5602498 )
MyD88 deficiency (TLR5) (R-HSA-5602680 )
IRAK4 deficiency (TLR5) (R-HSA-5603037 )
IRAK4 deficiency (TLR2/4) (R-HSA-5603041 )
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (R-HSA-6811558 )
Interleukin-1 signaling (R-HSA-9020702 )
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (R-HSA-975110 )
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (R-HSA-975138 )
MyD88 dependent cascade initiated on endosome (R-HSA-975155 )
MyD88 cascade initiated on plasma membrane (R-HSA-975871 )
ER-Phagosome pathway (R-HSA-1236974 )

References

1 Myeloid-MyD88 Contributes to Ethanol-Induced Liver Injury in Mice Linking Hepatocellular Death to Inflammation. Alcohol Clin Exp Res. 2017 Apr;41(4):719-726.