Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBLG3H)

• DTT Name: P120 messenger RNA (NOP2 mRNA)
• Synonyms: Proliferation-associated nucleolar protein p120 (mRNA); Proliferating-cell nucleolar antigen p120 (mRNA); Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (mRNA); Nucleolar protein 2 homolog (mRNA); Nucleolar protein 1 (mRNA); NSUN1 (mRNA); NOL1 (mRNA)
• Gene Name: NOP2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: NOP2_HUMAN
• TTD ID: T97044
• EC Number: EC 2.1.1.-
• Sequence:
  MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVE
  APKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDS
  EEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQW
  SEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVH
  KRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEF
  LEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPE
  YLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAE
  RLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKD
  EKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLV
  PTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSE
  TATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSE
  LSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPP
  KGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGP
  QPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS
• Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. Involved in ribosomal large subunit assembly.
• Reactome Pathway:
  TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation (R-HSA-8869496)
  rRNA modification in the nucleus and cytosol (R-HSA-6790901)

Molecular Interaction Atlas (MIA) of This DTT

4 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 6739	DM0B4RD	Discovery agent	N.A.	Investigative	[1]
ISIS 6748	DMQONPU	Discovery agent	N.A.	Investigative	[1]
ISIS 6755	DM4LD1Y	Discovery agent	N.A.	Investigative	[1]
ISIS 6756	DMRM5QH	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 5,814,619, Oligonucleotide inhibition of P120.