Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBQMJ8)

DTT Name	Glucose-6-phosphatase (G6PC)
Synonyms	Glucose-6-phosphatase alpha; G6Pase-alpha; G6Pase; G6PT; G-6-Pase
Gene Name	G6PC
DTT Type	Clinical trial target	[1]
BioChemical Class	Phosphoric monoester hydrolase
UniProt ID	G6PC_HUMAN
TTD ID	T85221
EC Number	EC 3.1.3.9
Sequence	MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ VVAGVLSGIAVAETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL
Function	Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum.
KEGG Pathway	Glycolysis / Gluconeogenesis (hsa00010 ) Galactose metabolism (hsa00052 ) Starch and sucrose metabolism (hsa00500 ) Metabolic pathways (hsa01100 ) FoxO signaling pathway (hsa04068 ) PI3K-Akt signaling pathway (hsa04151 ) AMPK signaling pathway (hsa04152 ) Insulin signaling pathway (hsa04910 ) Adipocytokine signaling pathway (hsa04920 ) Glucagon signaling pathway (hsa04922 ) Insulin resistance (hsa04931 ) Carbohydrate digestion and absorption (hsa04973 )
Reactome Pathway	Gluconeogenesis (R-HSA-70263 ) FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (R-HSA-9615017 ) Glycogen storage disease type Ia (G6PC) (R-HSA-3274531 )
BioCyc Pathway	MetaCyc:HS05538-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTX401	DM8WBNF	Pompe disease	5C51.3	Phase 1	[2]
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References

1	The antihyperglycemic effect of estrone sulfate in genetically obese-diabetic (ob/ob) mice is associated with reduced hepatic glucose-6-phosphatase. Horm Metab Res. 2001 Dec;33(12):721-6.
2	Clinical pipeline report, company report or official report of Ultragenyx Pharmaceutical.