Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTBYJ39)

DTT Name	HUMAN NADH:ubiquinone oxidoreductase subunit B9 (NDUFB9)
Synonyms	NADH-ubiquinone oxidoreductase B22 subunit; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; LYR motif-containing protein 3; Complex I-B22; CI-B22
Gene Name	NDUFB9
BioChemical Class	Complex I LYR family
UniProt ID	NDUB9_HUMAN
TTD ID	T01465
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKA TQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFA KREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM
Function	Human protein NADH:ubiquinone oxidoreductase subunit B9 interacts with SARS-CoV-2 Orf9c protein with high significance, which indicates NDUFB9 as a potential therapeutic target.
KEGG Pathway	Oxidative phosphorylation (hsa00190 ) Metabolic pathways (hsa01100 ) Thermogenesis (hsa04714 ) Retrograde endocannabinoid signaling (hsa04723 ) Non-alcoholic fatty liver disease (hsa04932 ) Alzheimer disease (hsa05010 ) Parkinson disease (hsa05012 ) Amyotrophic lateral sclerosis (hsa05014 ) Huntington disease (hsa05016 ) Prion disease (hsa05020 ) Pathways of neurodegeneration - multiple diseases (hsa05022 ) Chemical carcinogenesis - reactive oxygen species (hsa05208 ) Diabetic cardiomyopathy (hsa05415 )
Reactome Pathway	Complex I biogenesis (R-HSA-6799198 ) Respiratory electron transport (R-HSA-611105 )
BioCyc Pathway	MetaCyc:HS07466-MON

References

1	A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.