Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTC214J)

• DTT Name: Lysosome-associated membrane glycoprotein 1 (CD107a)
• Synonyms: Lysosomeassociated membrane protein 1; Lysosomeassociated membrane glycoprotein 1; Lysosome-associated membrane protein 1; LAMP-1; CD107 antigenlike family member A; CD107 antigen-like family member A
• Gene Name: LAMP1
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Lysosomal protein import
• UniProt ID: LAMP1_HUMAN
• TTD ID: T31145
• Sequence:
  MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGP
  KNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVY
  NLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLS
  NSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQL
  NLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFF
  LQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQ
  AFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
• Function: Implicated in tumor cell metastasis. Presents carbohydrate ligands to selectins.
• KEGG Pathway:
  Autophagy - animal (hsa04140)
  Lysosome (hsa04142)
  Phagosome (hsa04145)
  Tuberculosis (hsa05152)
• Reactome Pathway: Neutrophil degranulation (R-HSA-6798695)

References

• [1] Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated a... Oncotarget. 2016 Aug 30;7(35):56584-56597.