Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTC5LTG)

DTT Name	Interleukin-27 (IL27)
Synonyms	UNQ3096/PRO21175; Interleukin27; Interleukin17D; Interleukin-17D; IL-27; IL-17D
Gene Name	IL17D
DTT Type	Clinical trial target	[1]
BioChemical Class	Cytokine: interleukin
UniProt ID	IL17D_HUMAN
TTD ID	T41171
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQLYGRLAAGVLSAFHHTLQL GPREQARNASCPAGGRPADRRFRPPTNLRSVSPWAYRISYDPARYPRYLPEAYCLCRGCL TGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEAYVTIPVGCTCVPEPEKDADSI NSSIDKQGAKLLLGPNDAPAGP
Function	Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.
KEGG Pathway	Cytokine-cytokine receptor interaction (hsa04060 ) C-type lectin receptor signaling pathway (hsa04625 ) JAK-STAT signaling pathway (hsa04630 ) IL-17 signaling pathway (hsa04657 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SRF388	DMQMO4N	Liver cancer	2C12	Phase 1	[2]
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References

1	IL-27-induced modulation of autoimmunity and its therapeutic potential. Autoimmun Rev. 2015 Dec;14(12):1131-1141.
2	Clinical pipeline report, company report or official report of Surface oncology.