General Information of Drug Therapeutic Target (DTT) (ID: TTCDFR1)

DTT Name S100 calcium-binding protein A3 (S100A3)
Synonyms S100E; Protein S-100E
Gene Name S100A3
DTT Type
Literature-reported target
[1]
BioChemical Class
S100 calcium-binding protein
UniProt ID
S10A3_HUMAN
TTD ID
T93537
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELATWTPTEFRECDYNKFMS
VLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ
Function Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.

References

1 Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate. Exp Ther Med. 2017 Jun;13(6):2812-2818.