Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCH81V)

DTT Name	Bacterial NADH-dependent enoyl-ACP reductase 1 (Bact fabI1)
Synonyms	NADH-dependent enoyl-ACP reductase 1; Enoyl-[acyl-carrier-protein] reductase [NADH] 1
Gene Name	Bact fabI1
DTT Type	Literature-reported target	[1]
BioChemical Class	CH-CH donor oxidoreductase
UniProt ID	FABI1_RHIME
TTD ID	T53578
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAQASGLMNGKRGVIMGVANNRSIAWGIAKALAEAGAEIALTWQGDALKKRVEPLAQELG AFMAGHCDVTDLATIDAVFSALEEKWGKIDFVVHAIAFSDKDELTGRYLDTSRDNFARTM DISVYSFTAVAARADRVMNDGGSILTLTYYGAEKVMPHYNVMGVAKAALEASVRYLAVDL GNRGIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLKRTVSIEEVGNSALYLLSDLS SGVTGEVHHVDSGYHTVGMKAVDAPDISVLKD
Function	A key enzyme of the type II fatty acid synthesis (FAS) system. Essential for bacterial metabolism and its sequence conservation across many bacterial species but distinctly different from those of mammalian fatty acid biosynthesis enzymes.
KEGG Pathway	Fatty acid biosynthesis (sme00061 ) Biotin metabolism (sme00780 ) Metabolic pathways (sme01100 ) Fatty acid metabolism (sme01212 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[1]
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References

1	Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.