Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCJTWF)

DTT Name	Insulin-like growth factor-binding protein 1 (IGFBP1)
Synonyms	Placental protein 12; PP12; KITLG; IGFBP-1; IGF-binding protein 1; IBP1; IBP-1
Gene Name	IGFBP1
DTT Type	Literature-reported target	[1]
BioChemical Class	Insulin-like growth factor binding
UniProt ID	IBP1_HUMAN
TTD ID	T15048
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCC PMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGS PESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIEL YRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIP GSPEIRGDPNCQIYFNVQN
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Reactome Pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 ) Post-translational protein phosphorylation (R-HSA-8957275 ) FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (R-HSA-9615017 ) ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994 )

References

1	The insulin-like growth factor system as a therapeutic target in colorectal cancer. Ann Oncol. 2002 Mar;13(3):349-56.