Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCO25G)

• DTT Name: Trace amine receptor 5 (TAAR5)
• Synonyms: hTaar5; Trace amine-associated receptor 5; TaR-5; Putative neurotransmitter receptor; PNR
• Gene Name: TAAR5
• DTT Type: Literature-reported target; [1]
• UniProt ID: TAAR5_HUMAN
• TTD ID: T60362
• Sequence:
  MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVS
  YFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLT
  SIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLS
  QWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSL
  AGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSAC
  NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
• Function: Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
• KEGG Pathway: Neuroactive ligand-receptor interaction (hsa04080)
• Reactome Pathway:
  G alpha (s) signalling events (R-HSA-418555)
  ADORA2B mediated anti-inflammatory cytokines production (R-HSA-9660821)
  Amine ligand-binding receptors (R-HSA-375280)

Molecular Interaction Atlas (MIA) of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dimethylethylamine	DM2HYEN	Discovery agent	N.A.	Investigative	[1]
trimethylamine	DM8LJ3C	Discovery agent	N.A.	Investigative	[2]

References

• [1] Trace amine-associated receptors and their ligands. Br J Pharmacol. 2006 Dec;149(8):967-78.
• [2] A second class of chemosensory receptors in the olfactory epithelium. Nature. 2006 Aug 10;442(7103):645-50.