Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCRJKY)

DTT Name	Voltage-gated calcium channel (Cav)
Gene Name	Cav
DTT Type	Successful target	[1]
BioChemical Class	Voltage-gated ion channel
UniProt ID	NOUNIPROTAC
TTD ID	T62945

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolperisone	DMA2GHJ	Muscle spasm	MB47.3	Approved	[1]
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2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eperisone	DM1SMAI	Muscle spasm	MB47.3	Phase 3	[2]
GCC-1290K	DMJ7WRI	Parkinson disease	8A00.0	Phase 1	[3]
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References

1	Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46.
2	Suppression of calcium current in a snail neurone by eperisone and its analogues. Eur J Pharmacol. 1989 Sep 22;168(3):299-305.
3	Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34.