Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTD6SZ8)

• DTT Name: Runt-related transcription factor 2 (RUNX2)
• Synonyms: SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha Asubunit; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2A; PEBP2-alpha A; PEA2-alpha A; Osteoblast-specific transcription factor 2; Oncogene AML-3; OSF2; OSF-2; Core-binding factor subunit alpha-1; CBFA1; CBF-alpha-1; Acute myeloid leukemia 3 protein; AML3
• Gene Name: RUNX2
• DTT Type: Literature-reported target; [1]
• UniProt ID: RUNX2_HUMAN
• TTD ID: T02259
• Sequence:
  MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQ
  QQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPN
  FLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVA
  RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPS
  LFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYD
  QSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKS
  QAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHT
  YLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGS
  TLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY
• Function: Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation. Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis.
• KEGG Pathway:
  Parathyroid hormone synthesis, secretion and action (hsa04928)
  Transcriptional misregulation in cancer (hsa05202)
• Reactome Pathway:
  Transcriptional regulation by RUNX2 (R-HSA-8878166)
  RUNX1 regulates transcription of genes involved in differentiation of myeloid cells (R-HSA-8939246)
  Regulation of RUNX2 expression and activity (R-HSA-8939902)
  RUNX2 regulates osteoblast differentiation (R-HSA-8940973)
  RUNX2 regulates chondrocyte maturation (R-HSA-8941284)
  RUNX2 regulates bone development (R-HSA-8941326)
  RUNX2 regulates genes involved in cell migration (R-HSA-8941332)
  RUNX2 regulates genes involved in differentiation of myeloid cells (R-HSA-8941333)
  YAP1- and WWTR1 (TAZ)-stimulated gene expression (R-HSA-2032785)

References

• [1] RUNX2 and Osteosarcoma. Anticancer Agents Med Chem. 2015;15(7):881-7.