Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTD96RW)

• DTT Name: Hepatocyte growth factor activator (HGFAC)
• Synonyms: Hepatocyte growth factor activator long chain; HGFAC; HGFA; HGF activator
• Gene Name: HGFAC
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Peptidase
• UniProt ID: HGFA_HUMAN
• TTD ID: T38584
• EC Number: EC 3.4.21.-
• Sequence:
  MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILV
  TSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLH
  ACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQD
  PQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGT
  RHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVAST
  SASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE
  YCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHP
  WLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIE
  KYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGW
  GHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGG
  PLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
• Function: Activates hepatocyte growth factor (HGF) by convertingit from a single chain to a heterodimeric form.
• Reactome Pathway: MET Receptor Activation (R-HSA-6806942)

References

• [1] Hepatocyte growth factor activator inhibitor type 1 in cancer: advances and perspectives (Review). Mol Med Rep. 2014 Dec;10(6):2779-85.