Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDAKTW)

• DTT Name: Sperm-associated antigen 6 (SPAG6)
• Synonyms: Sperm flagellar protein; SPAG6; Repro-SA-1; Protein PF16 homolog
• Gene Name: SPAG6
• DTT Type: Literature-reported target; [1]
• UniProt ID: SPAG6_HUMAN
• TTD ID: T01151
• Sequence:
  MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT
  AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA
  IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE
  IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS
  VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID
  CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL
  GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF
  LYDAPPNILKHVVGQFSKVLPHDSKARRLFVTSGGLKKVQEIKAEPGSLLQEYINSINSC
  YPEEIVRYYSPGYSDTLLQRVDSYQPLNN
• Function: Important for structural integrity of the central apparatus in the sperm tail andfor flagellar motility.

References

• [1] SPAG6 regulates cell apoptosis through the TRAIL signal pathway in myelodysplastic syndromes. Oncol Rep. 2017 May;37(5):2839-2846.