Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDB8PW)

DTT Name	Apolipoprotein L1 messenger RNA (APOL1 mRNA)
Synonyms	Apolipoprotein L (mRNA); Apo-L (mRNA); ApoL (mRNA); Apolipoprotein L-I (mRNA); ApoL-I (mRNA)
Gene Name	APOL1
DTT Type	Clinical trial target	[1]
BioChemical Class	mRNA target
UniProt ID	APOL1_HUMAN
TTD ID	T63160
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTM DPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLAR QMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSG SLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQA HDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHAS ASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLH EGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
Function	May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
KEGG Pathway	8542 (hsa )
Reactome Pathway	( ) (R-HSA-2168880 ) (R-HSA-381426 ) (R-HSA-8957275 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ION532	DMC8UPL	Chronic kidney disease	GB61	Phase 1	[1]
------------------------------------------------------------------------------------

References

1	Clinical pipeline report, company report or official report of Ionis