Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDO3RC)

DTT Name	MMP2 messenger RNA (MMP2 mRNA)
Synonyms	TBE-1 (mRNA); Matrix metalloproteinase 2 (mRNA); Gelatinase A (mRNA); CLG4A (mRNA); 72 kDa type IV collagenase (mRNA); 72 kDa gelatinase (mRNA)
Gene Name	MMP2
DTT Type	Literature-reported target	[1]
BioChemical Class	mRNA target
UniProt ID	MMP2_HUMAN
TTD ID	T58074
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.4.24.24
Sequence	MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
Function	As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture.
KEGG Pathway	Endocrine resistance (hsa01522 ) Leukocyte transendothelial migration (hsa04670 ) GnRH signaling pathway (hsa04912 ) Estrogen signaling pathway (hsa04915 ) Relaxin signaling pathway (hsa04926 ) AGE-RAGE signaling pathway in diabetic complications (hsa04933 ) Pathways in cancer (hsa05200 ) Proteoglycans in cancer (hsa05205 ) Bladder cancer (hsa05219 ) Diabetic cardiomyopathy (hsa05415 ) Fluid shear stress and atherosclerosis (hsa05418 )
Reactome Pathway	Degradation of the extracellular matrix (R-HSA-1474228 ) Activation of Matrix Metalloproteinases (R-HSA-1592389 ) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 ) EPH-ephrin mediated repulsion of cells (R-HSA-3928665 ) Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807 ) Extra-nuclear estrogen signaling (R-HSA-9009391 ) Collagen degradation (R-HSA-1442490 )
BioCyc Pathway	MetaCyc:HS01565-MON

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Prostate cancer	2C82	Prostate	3.15E-02	-0.29	-0.56
Renal cancer	2C82	Kidney	1.23E-01	-0.29	-1.11
Sarcoma	2C82	Muscle tissue	3.48E-16	-0.11	-0.43
Lung cancer	2C82	Lung tissue	8.17E-01	0.03	0.1
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Matrix metalloproteinase-2 (MMP-2) DME Info

Gene Name

MMP2

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amylin	DMWDEN0	N. A.	N. A.	Phase 4	[2]
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References

1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.
2	Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide. J Biol Chem. 2013 Feb 1;288(5):3553-9.