Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDP8YM)

• DTT Name: Sialyltransferase 8D (ST8SIA4)
• Synonyms: Sialyltransferase St8Sia IV; ST8SiaIV; SIAT8D; SIAT8-D; Polysialyltransferase-1; PST1; PST; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; Alpha-2,8-sialyltransferase 8D
• Gene Name: ST8SIA4
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Glycosyltransferases
• UniProt ID: SIA8D_HUMAN
• TTD ID: T03593
• EC Number: EC 2.4.99.-
• Sequence:
  MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
  SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
  SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
  VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
  NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
  WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
• Function: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
• Reactome Pathway:
  NCAM1 interactions (R-HSA-419037)
  Sialic acid metabolism (R-HSA-4085001)

References

• [1] Alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice. Cancer Immunol Immunother. 2017 Jan;66(1):63-75.