Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TTDQPXA)
DTT Name | Connexin-23 (Cx23) | ||||
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Synonyms | Putative gap junction epsilon-1 protein | ||||
Gene Name | GJE1 | ||||
DTT Type |
Literature-reported target
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[1] | |||
BioChemical Class |
Gap junction-forming connexin
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UniProt ID | |||||
TTD ID | |||||
3D Structure | |||||
Sequence |
MSLNYIKNFYEGCVKPPTVIGQFHTLFFGSIRIFFLGVLGFAVYGNEALHFICDPDKREV
NLFCYNQFRPITPQVSFSALQLVIVLVPGALFHLYAACKSINQECILQKPIYTIIYILSV LLRISLAAIAFWLQIYLFGFQVKSLYLCDARSLGENMIIRCMVPEHFEKTIFLIAINTFT TITILLFVAEIFEIIFRRLYFPFRQ |
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Function | Does not form functional gap junctions. Mediates calcium-independent ATP release, suggesting activity as a hemichannel. | ||||
Molecular Interaction Atlas (MIA) of This DTT
Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
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1 Investigative Drug(s) Targeting This DTT
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