General Information of Drug Therapeutic Target (DTT) (ID: TTDQPXA)

DTT Name Connexin-23 (Cx23)
Synonyms Putative gap junction epsilon-1 protein
Gene Name GJE1
DTT Type
Literature-reported target
[1]
BioChemical Class
Gap junction-forming connexin
UniProt ID
CXE1_HUMAN
TTD ID
T46395
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLNYIKNFYEGCVKPPTVIGQFHTLFFGSIRIFFLGVLGFAVYGNEALHFICDPDKREV
NLFCYNQFRPITPQVSFSALQLVIVLVPGALFHLYAACKSINQECILQKPIYTIIYILSV
LLRISLAAIAFWLQIYLFGFQVKSLYLCDARSLGENMIIRCMVPEHFEKTIFLIAINTFT
TITILLFVAEIFEIIFRRLYFPFRQ
Function Does not form functional gap junctions. Mediates calcium-independent ATP release, suggesting activity as a hemichannel.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
octanol DMBGHPE Discovery agent N.A. Investigative [1]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 714).