Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDRZ9H)

DTT Name	Transgelin (TAGLN)
Synonyms	TAGLN; Smooth muscle protein 22-alpha; SM22-alpha; Protein WS3-10; 22 kDa actin-binding protein
Gene Name	TAGLN
DTT Type	Literature-reported target	[1]
BioChemical Class	Calponin family
UniProt ID	TAGL_HUMAN
TTD ID	T93292
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGV ILSKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEG KDMAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKHVIGLQMG SNRGASQAGMTGYGRPRQIIS
Function	Actin cross-linking/gelling protein. Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.

References

1	Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression. BMC Cell Biol. 2013 Mar 19;14:17.