Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDU0HP)

• DTT Name: Bacterial Cystathionine gamma-synthase (Bact metB)
• Synonyms: metB; O-succinylhomoserine (Thiol)-lyase; CGS
• Gene Name: Bact metB
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Alkyl aryl transferase
• UniProt ID: METB_ECOLI
• TTD ID: T67942
• EC Number: EC 2.5.1.48
• Sequence:
  MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRA
  LAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVL
  FVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPA
  LQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL
  LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAML
  SFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLL
  RISTGIEDGEDLIADLENGFRAANKG
• Function: Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia.
• KEGG Pathway:
  Cysteine and methionine metabolism (ecj00270)
  Selenocompound metabolism (ecj00450)
  Sulfur metabolism (ecj00920)
  Metabolic pathways (ecj01100)
  Biosynthesis of secondary metabolites (ecj01110)
  Biosynthesis of amino acids (ecj01230)
• BioCyc Pathway:
  MetaCyc:O-SUCCHOMOSERLYASE-MON
  EcoCyc:O-SUCCHOMOSERLYASE-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GW-3333	DM3PMAZ	Chronic obstructive pulmonary disease	CA22	Preclinical	[1]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[2]

References

• [1] Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.